Monotherapy Or Chemotherapy Adjunct: Pembrolizumab In Advanced NSCLC

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Monotherapy Or Chemotherapy Adjunct: Pembrolizumab In Advanced NSCLC Objectives To assess the effectiveness and safety of pembrolizumab monotherapy and in combination with chemotherapy in patients with advanced non–small-cell lung cancer (NSCLC).  Introduction Historically, patients with advanced NSCLC have a poor prognosis despite the use of platinum-based chemotherapy drugs. The 5-year relative survival rate of

Sinonasal B‐cell lymphomas: A Cohort Study on Progression and Recurrence

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Sinonasal B‐cell lymphomas: A Cohort Study on Progression and Recurrence STUDY BACKGROUND Sinonasal lymphoma is a rare malignancy of rhinologic origin affecting the sinonasal region and surrounding structures. It is a type of non-Hodgkin lymphoma (NHL) comprising around 1.5% of all lymphomas and usually involves males aged between 40 and 70 years.

Metastatic Melanoma and Follow-Up MRI Scans

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Metastatic Melanoma and Follow-Up MRI Scans Metastatic melanoma is an aggressive tumor, which may spread to organs either by local invasion, or lymphatic or hematogenous dissemination. Central Nervous System (CNS), especially the brain, account for up to 50% of metastasis. Skin, lymph nodes, lung, and liver are other commonly involved organs,

Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report

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Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report Background Bipolar disorder is a multifactorial illness with uncertain etiology and geriatric new-onset manic episodes are highly associated with secondary organic causes. The presented case demonstrates the importance of excluding secondary causes during the entire disease course.  Overview Bipolar disorder is a

Anlotinib with Camrelizumab in Lung Cancer Treatment

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Anlotinib with Camrelizumab in Lung Cancer Treatment Background Checkpoint inhibitors (CPIs) and anti-angiogenic agents are emerging as potential novel treatment choices for advanced cancers including metastatic non-small-cell lung cancer (NSCLC). However, the combination of these two standard therapies has not been investigated in third-line or further-line treatment of patients with advanced NSCLC.

Diffuse-Type Tenosynovial Giant Cell Tumors: Treatments and Progression

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Diffuse-Type Tenosynovial Giant Cell Tumors: Treatments and Progression Tenosynovial giant cell tumors (TGCT) - An Introduction Tenosynovial giant cell tumors (TGCT) are rare, locally invasive lesions of synovial origin that involve joints, tendon sheaths, and bursae.  TGCT may be intra- or extra-articular and is classified by growth pattern and clinical presentation as

Renal Cell Carcinoma- Prognosis via Albumin Levels

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Renal Cell Carcinoma- Prognosis via Albumin Levels Metastatic renal cell carcinoma (mRCC) - An Introduction Renal cell carcinoma (RCC) constitutes approximately 90% of all urologic malignancies. Approximately 30% of patients with RCC present with metastatic disease, and amongst those with localized disease, a substantial proportion will recur. Before 2005, immunotherapy with interleukin-2

Hodgkin’s Lymphoma: A Case Study with Nystagmus and Diplopia

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Hodgkin's Lymphoma: A Case Study with Nystagmus and Diplopia INTRODUCTION Paraneoplastic neurologic syndromes (PNS) are uncommon but important clinical situations caused by cancer, but not a direct result of tumor invasion. As compared to solid tumors, the chances of association of PNS with lymphomas are quite low. However, Hodgkin's and non-Hodgkin's lymphomas,

Spence Children’s Anxiety Scale Validation

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Validation of Spence Children's Anxiety Scale ANXIETY IN CHILDREN In Europe, anxiety disorders are highly prevalent and impairing conditions among children and adolescents. Up to 18 - 20% of youth in the general population presenting to primary care clinics report some internalizing problem. Previous studies showed that anxiety disorders start at an early

Koolen-de Vries Case Study

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Koolen-de Vries syndrome in a 63-year-old woman: a review of the adult phenotype Koolen-de Vries syndrome (KdVS): An Introduction Also known as the 17q21.31 microdeletion syndrome, Koolen-de Vries syndrome (KdVS) was first described in 2006 in individuals with intellectual disabilities and organ abnormalities. KdVS was initially described in association with recurrent microdeletion

Monotherapy Or Chemotherapy Adjunct: Pembrolizumab In Advanced NSCLC