Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy

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Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy Overview  Later-line treatments for advanced gastric cancer have always been debated. Although chemotherapy is the recommended option. For the last decade, immune checkpoint inhibitors have been used for the treatment of various malignancies. Trials have also been performed for gastric cancer. In this study, a

Platinum-Resistant Recurrent Ovarian Cancer Treatment +/- Bevacizumab

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Platinum-Resistant Recurrent Ovarian Cancer Treatment +/- Bevacizumab Overview Of The Study  The study aims to elucidate the efficacy of bevacizumab therapy in patients with platinum-resistant ovarian cancer whose disease has already progressed after bevacizumab plus chemotherapy therapy.  The study is a multicenter, open-label, phase II trial (JGOG3023).  Subjects were randomized 1:1 to single-agent

Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia

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Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia The difficulty of making an accurate prognosis of acute T- cell lymphoblastic leukemia (T- ALL) and T- cell lymphoblastic lymphoma (T- LBL) in seniors and patients with relapsed illness has always been an issue in the medical field. Since there is no specified standard

Ocular Melanoma and Treatment with Metformin

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Ocular Melanoma and Treatment with Metformin Metformin Activity  Metformin is one of the most common medications for patients with type 2 diabetes mellitus. It is an antihyperglycemic agent that activates the adenosine monophosphate-activated kinase (AMPK). Through this, a person’s cellular ATP levels are restored. The activation of AMPK by metformin suggests that

Gastric Neuroendocrine Neoplasms

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Gastric Neuroendocrine Neoplasms Overview Gastric neuroendocrine neoplasms are rare lesions found in the stomach. They grow slowly and are often divided into four types based on their clinical characteristics. Type I lesions are found in the stomach and are linked with autoimmune chronic atrophic gastritis. Type II lesions are often caused by

Sebaceous Carcinoma Treatment Outcomes: A Multicenter Study

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Sebaceous Carcinoma Treatment Outcomes Sebaceous carcinoma (SC) is a rare tumor found in the sebaceous glands. The sebaceous gland is the gland that lubricates our skin. Although it can develop anywhere on the body, sebaceous carcinomas are often found on eyelids. It’s responsible for 0.7% of all cutaneous malignancies. From 2000

Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report

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Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report Overview  A male patient, 52 years of age, underwent pneumonectomy of the left lung. He was previously diagnosed with primary spindle cell carcinoma (pT4aN1M0, stage III B) with programmed death-ligand 1 expression (tumor proportion score ≥95%) and without epidermal growth factor

DNA Methylation Profiling in Sarcoma Classification

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DNA Methylation Profiling in Sarcoma Classification Sarcomas are tissue and bone tumors that can be found in any part of the body and can affect people of all ages. They often grow in connective tissues or those cells whose primary role is to support other tissues in one’s body. Currently, there

Breast Tomosynthesis Simulator for Virtual Clinical Trials

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Breast Tomosynthesis Simulator for Virtual Clinical Trials Summary  The use of computer models and simulation in predicting the clinical performance of x-ray imaging devices in silico and generating synthetic patient images for training and testing of machine learning algorithms is widely accepted today.  In this study, the researchers presented a detailed description of

Diagnostic Error Causing Cases of Cytopenia

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Diagnostic Error Causing Cases of Cytopenia Summary  Many psychotropic drugs are known to cause cytopenia after increasing dosage or during the beginning of treatment. Cytopenia can also be caused by other conditions such as leukemia. These two case reports report on cases of cytopenia which happened during adjustment of psychotropic mediations in

Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy