Usual dose: (Medication must be given on an empty stomach. In order to provide adequate buffering, patients must take at least 2 of the appropriate strength tablets at each dose when using either the once daily or twice daily regimens. Patient weight <60 kg: (Tablets): 125 mg orally twice daily or 250mg once daily or 167 mg (Buffered powder) twice daily. Patient weight > 60kg: (Tablets): 200mg orally twice daily or 400mg orally once daily. (Buffered Powder): 250mg orally twice daily. Supplied: chewable tablet: (25, 50, 100, 150, and 200mg); Oral powder for solution (100, 167, and 200mg packets). Renal Dosing:
Usual dose: 150 mg orally twice daily. Supplied: [150mg tablet; 10 mg/ml oral solution]. Lamivudine should not be co-administered with zalcitabine. Renal dosing: crcl >50/ no change; 30-49/ 150mg once daily; 15-29/ 150mg x1, then 100mg once daily; 5-14/ 150mg x 1, then 50 mg once daily; <5/ 50mg x1, then 25mg once daily.
Dosing: Patient weight >60 kg: 40mg orally twice daily . Patient weight < 60kg: 30mg orally twice daily. Dosages may be decreased by 50% if peripheral neuropathy occurs. May be taken without regard to meals. Must decrease dose in renal dysfunction. Stavudine and Zidovudine should not be co-administered. Supplied: [15, 20, 30, 40mg capsules; 1 mg/ml oral powder for solution] Renal dosing:
Usual dose: 0.75 mg orally three times daily. Lamivudine should not be co-administered with zalcitabine. Renal dosing: >40/ no change; 10-40/ 0.75 mg twice daily; <10/ 0.75 mg once daily. Supplied: [0.375mg , 0.75mg tablet]
Usual dose: 300mg orally twice daily or 200mg orally three times daily or 100mg every 4 hours 5 times daily. Stavudine and Zidovudine should not be co-administered. Supplied: 100mg capsule; 300mg tablet; 50mg/5ml oral solution. Dosing in renal failure (<10 ml/min): 100mg every 6 to 8 hours.
Usual dose: 800mg orally every 8 hours or 1200mg orally twice daily (must be taken on an empty stomach). If administered with Rifabutin: give 1000mg orally every 8 hours. Supplied: [200, 333, and 400mg capsules]
Usual dose: To reduce the risk of nausea give 300mg orally twice a day for 1 day, then give 400mg orally twice a day for 2 days, then 500mg orally twice a day for 1 day, then finally 600mg twice daily thereafter. (Take with food). Supplied: [100mg capsule; 80mg/ml -240ml oral solution]