You are here
Home > Blog > Health Topics > Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report

Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report

Welcome to NewMedicalTerms, your ultimate guide to the explanations and definitions of the majority of medical terms you may see.

Feel free to use our complete database with charts, tables and examples.

Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report

Overview 

A male patient, 52 years of age, underwent pneumonectomy of the left lung. He was previously diagnosed with primary spindle cell carcinoma (pT4aN1M0, stage III B) with programmed death-ligand 1 expression (tumor proportion score ≥95%) and without epidermal growth factor receptor gene mutation and anaplastic lymphoma kinase fusion gene. Unfortunately, he later developed brain metastasis and chest wall tumor relapse. Considering insufficient improvement with gamma knife treatment for brain metastasis and combination chemotherapy (paclitaxel, carboplatin, and bevacizumab), pembrolizumab monotherapy, and palliative irradiation therapy for chest metastases were started after a brain tumor volume reduction using craniotomy. His brain edema and chest wall metastases improved after a pseudoprogression of the brain edema accompanied by a performance status decline. This effect continued until 11 cycles of pembrolizumab administration.

Case Report 

A 52-year old male patient who was an ex-smoker (34 packs/year) was diagnosed with a left lower lobe lung tumor. He was diagnosed with primary lung spindle cell carcinoma (SpCC; pT4aN1M0, stage III B), with programmed death-ligand 1 (PD-L1) expression (tumor proportion score [TPS] ≥95%) without epidermal growth factor receptor gene mutation and anaplastic lymphoma kinase fusion gene. 

Nine months after pneumonectomy he was found with brain metastasis in his right temporal lobe. This was despite receiving four cycles of cisplatin and vinorelbine as postoperative adjuvant chemotherapy. His brain metastasis was treated with gamma knife surgery. Radiation necrosis was suspected because no reduction was found in the size of his tumor and perifocal edema. His chest wall metastases were found to increase 10 months after his pneumonectomy. Despite combination chemotherapy (paclitaxel, carboplatin, and bevacizumab) given as first-line chemotherapy 14 months after pneumonectomy, his brain edema progressively worsened. 

Because of this, the doctors decided to perform craniotomy and brain tumor volume reduction. His pathological examination revealed that he has metastatic lung carcinoma with necrosis. Throughout that period, chest wall metastases progressively increased in size; the patient had a performance status (PS) score of 2. Pembrolizumab monotherapy (200 mg/ bodyweight, every three weeks) was started as second-line chemotherapy one month after craniotomy. Palliative irradiation therapy (30 Gy/10 fr) to the chest wall was also performed from Day 3 after pembrolizumab monotherapy initiation. 

From Day 1, he developed a severe fever and exhibited appetite loss, general fatigue, and consciousness impairment (drowsy state) (PS score increased to 4). On Day 8, brain computed tomography (CT) showed an exacerbation of the brain edema. Given the lack of improvement in fever despite antibiotic treatment, the fever was suspected to be associated with the tumor or reactive against pembrolizumab. To control the fever, naproxen was administered. The fever and consciousness level gradually improved, and he was discharged on Day 30.

He was given two cycles of pembrolizumab monotherapy where his appetite and PS began to improve. His chest CT showed larger chest wall tumors than those after initial pembrolizumab administration. His PS score improved to two after five cycles, and chest and brain CT showed a reduction in the chest wall tumor size and brain edema. 

After 12 and 15 cycles of pembrolizumab, brain magnetic resonance imaging showed new brain metastasis and chest wall tumor regrowth. Therefore, pembrolizumab monotherapy was stopped, and another round of gamma knife treatment for the brain metastases was performed. Despite recommending cytotoxic chemotherapies, the patient refused and died four months after pembrolizumab monotherapy. 

Findings and Observations

After being diagnosed with lung SpCC the patient developed recurrence nine months after his pneumonectomy. The problem started because his recurrent lesions were refractory to irradiation and chemotherapy. In 2015, the World Health Organization classified pulmonary SpCC as a sarcomatoid carcinoma, comprising an almost pure population of epithelial spindle cells, without differentiated carcinomatous elements. Sarcomatoid carcinomas are rare (<1% of all lung cancers), have a poor prognosis, and are resistant to cytotoxic chemotherapy. 

In the current case, the resected tumor showed high PD-L1 expression and a significant therapeutic response to pembrolizumab. Sarcomatoid carcinomas, including the sarcomatous area of pleomorphic carcinomas, show high PD-L1 expression and have a poor prognosis. Pembrolizumab, an immune checkpoint inhibitor (ICI), is a highly selective, humanized, immunoglobulin G4 monoclonal antibody against programmed cell death. 

Despite the proven efficacy of pembrolizumab monotherapy against PD-L1-expressing non–small cell lung cancer (NSCLC) with a TPS of ≥1%, information regarding its effects against lung SpCC is scarce. Meanwhile, pembrolizumab monotherapy effectively decreased lung and metastatic tumors in a patient with SpCC. Furthermore, ICIs showed effects against sarcomatoid lung carcinoma and mesothelioma. The current case developed brain metastases, resistant to irradiation, and exhibited radiation necrosis. 

Patients with NSCLC who develop brain metastases have a poor prognosis and survival. As metastatic brain tumors are protected by the blood-brain barrier (BBB), ICI efficacy remains unclear. BBB is often compromised in patients with brain metastases and is subsequently remodeled into a blood–tumor barrier, altering the immune cell population around brain metastases. Moreover, ICIs possibly exert a suppressive effect on the progression of central nervous system tumors despite no established evidence that demonstrates the efficacy of ICI against brain metastases. Therefore, pembrolizumab penetration into the brain tumor as possible in this case because BBB was disrupted by the preceding brain tumor resection.

In the current case, brain edema exacerbated with PS decline, following initial pembrolizumab administration. Initial ICI treatment for brain metastases often shows a pseudoprogression within the first three months. Pseudoprogression of brain metastases has been explained histologically by inflammatory cell infiltration, edema, and necrosis, and radiologically by a frequent exhibition of perilesional brain edema. A careful therapeutic response evaluation is thus recommended to avoid progressive disease six months or less after ICI administration initiation. Although it is difficult to distinguish the contribution of the abscopal effect by palliative irradiation therapy to the chest wall, exacerbation of brain edema could be explained adequately by pseudoprogression of ICI.

Although brain edema exacerbation frequently induces PS decline, a pseudoprogression would usually exhibit a subsequent improvement. Therefore, a pseudoprogression should be considered to make appropriate decisions regarding ICI administration continuation. Lung SpCC has a poor prognosis and is usually resistant to cytotoxic chemotherapy. Our findings suggest ICI therapy as a novel therapeutic strategy for lung SpCC. Furthermore, given that pseudoprogression with PS decline is commonly observed in brain metastases treated with ICIs, the therapeutic response should be carefully evaluated to determine whether ICI can be continued.

Oncology Related Tools


Other


Latest Research


Lung Spindle Cell


Similar Articles

Leave a Reply